As attackers become increasingly aggressive nowadays, the workload for defenders (the blue team) is growing, with the need to juggle internal operations and protection while also ensuring user endpoint security and defending against sensitive information leaks resulting from successful social engineering attacks. How can we use Microsoft Defender to reduce our burden and leverage the collaborative defense features of various protection mechanisms, implement effective SOAR, and adapt to modern working patterns in order to enhance our defense capabilities? We have designed scenarios involving malicious programs, identity theft, ransomware, and sensitive data tracking. These scenarios enable you to experience how Microsoft's modernized security work surface can help you quickly conduct effective inventory assessments, vulnerability scans, and automatic protection, achieving comprehensive protection, fearless transformation, and effective construction of zero trust!