In recent years, malicious program attacks on the semiconductor manufacturing industry have become more serious and the subject of increasing attention. The industry’s heavy reliance on automated production combined with its tremendous economic value means that it faces great pressure to ensure high availability, high production capacity, and high yield rates. In January 2022, global semiconductor industry association SEMI launched the new SEMI E187 Equipment Information Security Standard, aimed at eliminating potential vulnerabilities that facilitate external supply chain attacks, internal threats, and network attacks. This seminar proposes a protection paradigm based on the asset life cycle, analyzes the key challenges accompanying the SEMI E187/E188 standards, and provides practical recommendations to help asset owners and equipment suppliers together achieve standard compliance.